FDA approved (Cala One). Employs electrodes on the median and radial nerves on the anterior and the posterior surfaces of the wrist. Electrical stimulation induces halamicneuronal oscillations and disrupt the pathological oscillations of tremors. The company’s transcutaneous afferent patterned stimulation (TAPS) therapy sends patterned signals to the brain across the skin to stimulate the thalamus. An accelerometer within this device measures the frequency of the patient’s tremor, allowing calibration of the stimulation intensity. Patients wear the device for 40-minute sessions throughout the day as needed. A study of 5 patients showed a 57% tremor suppression. Over time, the stimulation normalized neural firing to reduce tremors.

FDA trial. Vibrotactile Coordinated Reset stimulation. Stimulates the sensory nerves (responsible for limb position awareness) which are connected to the thalamus (implicated in tremors). Coordinated Reset shown to have sustained benefits (ref Tass et al 2012)