Providing resources and ideas for therapies and medical developments for Parkinson's disease:
There is a reported link between specific industrial neurotoxins and agricultural pesticides/herbicides and neurodegenerative diseases such as Parkinson's. One can have a urine test to detect for elevated levels of these neurotoxins. While the association between many toxic chemicals and cancer are well known, the association to Parkinson's is less evident. While the association with cancer should be enough to want to avoid chemical toxins, we will only be covering those affiliated with Parkinson's.
There are some stong corellations with certain industrial trades and Parkinson's disease. Aerospace workers woring with the solvent trichloroethylene were found to be six times more likely to develop Parkinson's. (ref: Solvent exposure) Farm workers who work with herbicides and pesticides are at an elevated risk of getting Parkinson's disease. One study showed that those lived in a home five hundred meters from a farm field which employed the use of the weed killer Paraquat or maneb, had an increased risk of Parkinson's disease of 75% compared to the general population! (ref: Parkinson's Disease and Residential Exposure) Farm workers who handled the herbicide were at an increased risk of 250%! (ref: Rotenone, Paraquat, and Parkinson’s Disease)
The list of toxic chemical associations are growing and so is their use.
|Carbon Monoxide||Carbon Monoxide poisoning or even elevated levels of exposure are linked to the development of Parkinson's.
|Breath clean air|
|Glyphosate||Glyphosate is the active ingredient in the weed killer "Round Up" and had been found in multiple studies to be linked as a cause of Parkinson's disease.
Washington State University study:
Webinar recording: Glyphosate, the main ingredient in herbicides and Parkinson’s Disease and Beyond - Dr Shanhong Lu MD PhD
|Glutathion, activated charcoal|
|Paraquat||This herbicide is associated with mitochondrial dysfunction and oxidative stress affecting Parkinson's.
Exposure to Paraquat increases the risk of Parkinson's by 150%.
Destroys dopamine producing neurons in the substantia nigra in a similar fashion to MPTP and MPP+.
Chemically similar to Rotenone and MPP+.
|Rotenone||This insecticide is associated with mitochondrial dysfunction and oxidative stress affecting Parkinson's.
Rotenone can cross cell membranes and is therefore likely able to affect all cells.
Rotenone is commonly used to treat parasitic mites on chickens and other fowl, and so can be found in poultry.
Also used by fisheries to eliminate invasive fish species.
Chemically similar to Paraquat and MPP+.
|Permethrin (3PB)||This incecticide has been associated with Parkinson's.
Studies on rats showed decreased levels of dopamine in the striatum, loss of dopaminergic neurons in the substantia nigra pars compacta and cognitive impairments.
|Organophosphorus Pesticides||Organophosphorous pesticides are used in agriculture and in household pesticides and are significantly associated with Parkinson's Disease.
The frequent use of household pesticides that contain organophosphorus chemicals increased the chances of developing Parkinson's Disease by 71%.
Note that Chlorpyrifos, the organophosphate agent of dursban, is found in some popular household roach and ant sprays, including Raid and Black Flag.
Organophosphates exert their toxic effects by inhibiting the activity of acetylcholinesterase at nerve endings, leading to the accumulation of the neurotransmitter acetylcholine, and affecting the parasympathetic, sympathetic, motor, and central nervous systems. Also see Genetic links and gene PON1-55 for susceptibility to organophosphates.
Reference: Household Organophosphorus Pesticide Use and Parkinson's Disease
|Enzymatic detoxification of organophosphorus pesticides and related toxicants|
|Organochlorine: beta-hexachlorocyclohexane||This pesticide has been implicated as environmental risk factor for the development of Parkinson’s disease (with a small sample size).
Reference: β-Hexachlorocyclohexane Levels in Serum and Risk of Parkinson’s Disease
|2,4-dichlorophenoxyacetic acid (2,4-D)||This herbicide was a major component of Agent Orange used during the Vietnam war.|
|Manganese||High-dose manganese exposure is known to cause a form of parkinsonism called manganism.
This condition can be contracted in occupations such as welding.
Note that many daily multi-vitamins contain low doses of Manganese and it is an essential nutrient found in whole grains, legumes, beans, nuts, ...
|Diatomaceous Earth, Organic Silica|
|Lead||Lead has been associated with an elevated risk of Parkinson's.
Reference: Chronic Lead Exposure Increases Risk of Parkinson Disease
|Activated charcoal, ethylenediaminetetraacetic acid (EDTA), Cytodetox, NAC, R-Alpha Lipoic Acid, Niacin|
|Mercury||Mercury has been associated with an elevated risk of Parkinson's symptoms and overall oxidative stress and cell death.
NAD, Glutathione or chlorella
Also see Mercury chelation
|Iron||Wang and colleagues (2017) stated that iron accumulation in substantia nigra pars compacta (SNpc) has been proved to be a prominent pathophysiological feature of Parkinson's diseases, which can induce the death of dopaminergic neurons, up-regulation of reactive oxygen species (ROS), and further loss of motor control.
|Iron chelation therapy with PMPC to delay the saturation of iron chelators and prolong the in-vivo lifetime.|
|Trichloroethylene (TCE)||This solvent can be found in degreasing agents, dry cleaning fluid and paint thinners.
It is also used to extract vegetable oils, in coffee decaffeination, and the preparation of flavouring extracts from hops and spices.
Those exposed during employment are six times more likely to develop Parkinson's disease.
Trichloroethylene is a significant component of 50% of the superfund sites in the US including silicon valley where it was used in the cleaning and processing of silicon chips.
|Glutathion, activated charcoal|
|polychlorinated biphenyls (PCBs)||This fire retardant is banned but has been found in high concentrations in the brains of people who had Parkinson’s.
|Tiglylglycine (TG)||This compound is a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA, which can manifest from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies. TG indicates mitochondrial dysfunction by monitoring a metabolite that is elevated in mitochondrial deficiency of cofactors such as NAD+, flavin-containing coenzymes, and Coenzyme Q10. Disorders associated with mitochondrial dysfunction include autism, Parkinson’s disease, and cancer (as stated by Great Plains Labs but could not find any other literature expressing this connection).|
|MPTP||This chemical is derived from the production of synthetic heroine and has a direct and immediate effect in the cause of symptoms of parkinsonism.
Neurologists discovered this link when a group of intravenous drug users in California in the 1980s injected a synthetic heroin that had been contaminated with MPTP.
MPTP is associated with mitochondrial dysfunction.
In research, MPTP is often used to cause Parkinson's in lab rats.
While it is a dangerous chemical, it is not found by accidental exposure.
Reference: MPTP-Induced Parkinsonian Syndrome
|1-methyl-4-phenylpyridinium (MPP+)||This chemical is a neurotoxin associated with mitochondrial dysfunction. It is a compound closely related to MPTP.
Chemically similar to the pesticides Rotenone and Paraquat.
|Lipopolysaccharide (LPS)||This chemical is a bacterial endotoxin (generated internal to the bacteria as opposed to exotoxins which are released by the bacteria) generated by the Gam-negative bacteria.
It is used in research as a glial activator for the induction of inflammatory dopaminergic neurodegeneration.
Causes nitrative stress and glial cell activation.
Reference: The Lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery (2008)
|Epoxomicin||This chemical is a naturally occurring selective proteasome inhibitor which inhibits a neuron cell's ability to clean-up alpha-synuclein.
Causes proteasomal and lysosomal dysfunction inducing Parkinson's symptoms.
There are many currently banned substances such as DDT, Agent Orange, heptachlor and dieldrin which were once in wide use and have contributed to Parkinson's in older patients.
These services often require a doctor's order for a test.
These services provide a doctor's order for a test.
The Environmental Working Group (EWG) runs an online database of toxins found in the drinking water based on US zip codes. The database is formed from 32 million state water records from nearly 50,000 utilities. Enter your US zip code on the EWG website.
Flouride has also been found to be an endocrine disruptor (it alters normal endocrine function and response) and a neurotoxin, although there has been no direct link to Parkinson's disease.
The detox regiment for each toxin is different. Heavy metals are typically removed using "Chelation therapy", a procedure that involves the administration of chelating agents to remove heavy metals from the body. Chelation therapies may have side effects which are worse than the toxin. Detox and chelation therapies should only be administered by a medical professional.
Saunas are often used as a detox therapy as sweat can be an exit corridor for toxins such as petrochemicals as well as metals. Since sweating in a sauna pulls a lot of electrolytes and minerals from your body, it's important to drink sufficient quantities of water as well as replenish salts and electrolytes.
Exercise is another promoter of sweat to flush toxins from the body. It also tends to burn body fat which will release additional toxins stored there so it is often paired up with chelating nutrients and supplements.
Activated Charcoal is a form of carbon which forms a bond with toxins. After bonding with toxins like mold toxins, BPA or pesticides, ingested charcoal can continue to pass through with your bowel movement to excrete both the activated charcoal and the toxins bonded to it. Also see binders
Diet which targets fat loss such as one that achieves ketosis will have a similar effect to exercise and can be coupled with activated charcoal to purge the toxins released from your fat.
Supplements such as Calcium-D Glucarate (liver detox), precursors to Glutathion (NAC, Glutamate, Glycine) and others have been known to help detoxify the body. Guidance from a health professional is crucial to helping detoxify your body and not causing further damage.
One might think that the detoxification process should be guided by a toxicologist medical doctor. Unfortunately that is not how the medical system is structured. Toxicologists are rare and associated with larger hospitals and medical institutions and fall under the Emergency Room (ER) jurisdiction. Thus one can not schedule a visit with a toxicologist as they consult with ER doctors primarily about overdoses and poisonings. Even in ER they rarely see patients and primarily act as consultants. This is very unfortunate as it forces many to work with holistic practitioners or on their own, guided by what they read on the internet at a time wen they need a doctor's guidance.Also see: