Providing resources and ideas for therapies and medical developments for Parkinson's disease:
The primary approach to treating Parkinson's disease is to prescribe drugs to treat Parkinson's symptoms, primarily tremors. There are no medical solutions to halt the progress of Parkinson's disease, nor is there a solution to reverse the damage done by Parkinson's disease. This website covers probiotics, unsafe environment avoidance or mitigation (eg mold, toxins), dieting for autophagy and exercise & physical therapy which are thought to help Parkinson's patients, but are not cures.
The cause of Parkinson's is the migration of a mis-folded alpha-synuclein protein which enters neuron cells and can't be expelled. The neuron cell eventually accumulates too much alpha-synuclein protein and burst and dies leaving behind "Lewy Bodies" as waste by-product. By the time Parkinson's is diagnosed, it is believed that 70% of the neurons in the substantia nigra have been killed.
It is belived that the source or entry point into the body of the mis-folded alpha-synuclein protein is the gut which then migrates along the vegus nerve to the base of the brain (ref Johns Hopkins research).
Research and drug trials are taking the following approach to the problem:
There seems to be approaches which are not being considered:
The following approach relies on a technology known as Pharmacoperone or Pharmacological chaperone. This technology uses a protein that enters cells and serves as a "molecular scaffold" to promote correct folding of otherwise-misfolded mutant proteins within the cell. This requires knowing the protein fold of mis-folded and correctly folded alpha-synuclein and then developing the Pharmacoperone protein.
Protein Folding: The University of Washington is the leader in protein design and protein folding. They have released many software packages for the study of this subject:
Once the protein to provide the "molecular scaffold" has been defined, traditional biotech science can be utilized to generate the protein as a drug. This requires DNA gene editing to define the amino acid sequencing to produce the the protein which provides the proper "molecular scaffold". The edited DNA is then inserted into a cell used as the molecular factory to synthesize the "molecular scaffold" protein. The next step is to provide a delivery mechanism to deliver this protein to the affected area (substantia nigra) to fix the mis-folded alpha-synucleins which are destroying neurons. This is hoped to halt the progression of Parkinson's. To make this approach optimal, it would have to be administered as soon as Parkinson's is detected necessitating new methods of early detection. I do not know of any research taking this approach but feel that it is an idea which can be improved and built upon.
Mercury chelation therapy is used to detoxify the body of mercury but also has the hazzard that it can "drop" mercury that it pulls out of tissue into the blood stream where it can be redistributed to vulnerable areas such as the brain. Building on sweating as natural excretion path for mercury, oral chelators like DMSA could be developed into topical transdermal creams to help pull mercury out with sweat and help prevent reabsorption. It seems that a topical transdermal chelator would be less likely to redistribute mercury to the brain. DMSA disolved in water and applied to the chest, belly and neck seemed to lead to a rash in the applied areas so work needs to be done to make the compound less irritating to the skin.